ABSTRACT
Pristimeim, as one major active chemical component of traditional Chinese medicine Celastrus aculeatus Men., has been reported to have pharmacological activities such as broad spectrum anti-tumor and anti-rheumatoid arthritis in recent years. In this article, we review the research articles of pristimerin on the characteristics and molecular mechanism of its pharmacological effects, aiming to make a reference for new drug development and clinical application.
ABSTRACT
Primary Sj?gren′s syndrome(pSS)is a chronic autoimmune disease which is characterized by exocrine gland dam-age.Studies have found that pSS is associated with a variety of autoantibodies,including anti-Ro/SSA,-La/SSB,-M3R,-α-fodrin,-AD-AMTS13,-NA-14,-IFN-γ,-REG Iα,-MDM2.In this paper,we reviewed the progress of autoantibodies in the diagnosis,disease prediction and pathogenesis of pSS in recent years,so as to provide new ideas for pSS clinical and scientific research.
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the protective effect of licoflavone on gastric mucosa in rats with chronic superficial gastritis and explore the possible mechanism.</p><p><b>METHODS</b>SD rat models of chronic superficial gastritis was established by intragastric administration of 0.02% ammonia and long-term irregular diet. The rat models were then randomized into model group, vitacoenzyme group and 3 licoflavone groups of high, medium, and low doses. After 30 days of treatment, the gastric histopathology, mucosal lesions, scanning electron microscopy, mucin function production by the gastric mucosa epithelial cells, serum PGE(2) level and gastric microcirculation were assessed to evaluate the protective effect of licoflavone on gastric mucosa.</p><p><b>RESULTS</b>Compared with normal control rats, the rat models of chronic superficial gastritis showed significantly higher gastric mucosal injury rate, histopathological scores and gastric mucin content. Licoflavone significantly ameliorated gastric pathology and increased serum PGE(2) level, enhanced acidic mucin secretion by the epithelial cells, and improved gastric microcirculation in the rat models.</p><p><b>CONCLUSION</b>Licoflavone feeding suppresses gastric mucosa injury, protects and restores the injured mucosa in rats with chronic superficial gastritis, and these effects are related with the up-regulation of serum PGE(2) level.</p>